|Roshan K||10-09-2019||comment profile send pm notify|
Alcohol excipients are inactive substances generally used as functional additives in pharmaceuticals. Excipient is inactive substance which is used with the active ingredients to improve absorption in body. Excipients also help to control the release of the active substances over a period of time if the treatment demands. As excipients are added to the formulations that contain active ingredients, they are also called bulking agents, fillers or diluents. They are also used to add flavor, and taste to certain pharmaceuticals.
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Alcohol excipients are also required to maintain the pH balance of the formulation, in order to optimize chemical stability and anti-microbial effectiveness. Some of the popular alcohol excipients include sorbitol, mannitol, propylene glycol, and glycerin among others. Excipients such as propylene glycol and glycerol are extensively used in aqueous suspensions and emulsions for external application. Generally excipients are passive substances in medicine and have no therapeutic value to the patient. However, they might have allergic effect on some patients based on the drug formulation.
Growing pharmaceutical industry and development of new alcohol excipients are expected to drive the market. Rising population and changing lifestyle is driving pharmaceutical industry in developing countries. Demand from developed countries is rising owing to government regulations and technological advances in pharmaceutical and biomedicine industry. Demand for glycerin as an excipient is expected to grow at a higher pace owing to growing application scope in medical applications. Sorbitol and propylene glycol account for the largest cumulative market share of alcohol excipients.
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However, high cost of manufacturing, declining R&D activities and supply issues are expected to hamper the market growth. There also exists a demand supply imbalance, and the price of glycerin is expected to decline due to over production. Rising demand for alcohol excipients in oral solid dosage form (OSDF) is expected to provide opportunities for the players in the near future. However, regulatory risks of alcohol excipients remain, as it is perceived to have some side effects with certain drug formulations.